The Setup is a cool new site with interviews from all kinds of nerd heroes: designers, photographers, engineers, programmers, and so on. The interviews are all structured basically the same. First, the interviewee is asked about what they do, and they usually answer by describing both their professional and personal lives (note how many of them mention their home office). Second, what hardware do they use? In the interviews I've read, this often means a list of 3-4 key devices. Finally, the interviewee mentions the software they use most often. This is where I've seen the most variation between interviews.
Here are some fun ones:
Paula Pell, NBC (she includes coffee as hardware)
why, Internet rodent (and author of the Poignant Guide to Ruby)
The full list is here. Enjoy!